Abstract Microglia dysfunction is implicated in several neurodegenerative disorders. including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP). CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene. which encodes a receptor required for the diff... https://www.dawnsdinners.com/product-category/descaling-pipe-spout/