Yes. Unopened, collagen powder usually lasts about two to three years; once opened, it is best used within one to two years. It does not suddenly turn toxic on the best-by date, but the protein slowly loses potency, and moisture can cause clumping, off smells, or mold. Always follow the date on your label and check the smell, color, and texture before use. https://www.biooptimalsupplements.com/blogs/article/understanding-the-expiration-of-collagen-powder